H2N2V1, 1957, Analysis, bibRecord, 000117

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Identifieur interne : 000117 ( 1957/Analysis ); précédent : 000116; suivant : 000118

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Auteurs : T. M. Tsfasman [Russie] ; S. G. Markushin [Russie] ; I. I. Akopova [Russie] ; Y. Z. Ghendon [Russie]

Source :

Journal of general virology [ 0022-1317 ] ; 2007.

RBID : Pascal:07-0486627

Descripteurs français

KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
Pascal (Inist)
- Acclimatation, Basse température, Grippe humaine, Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Recombinaison génétique, Test de complémentation, Virus grippal A, Mécanisme action, Réversion, Température, Phénotype, Souche, Microbiologie.

English descriptors

KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza A virus, Influenza, Human (immunology), Influenza, Human (prevention & control), Mechanism of action, Microbiology, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Reversion, Strain, Temperature, Viral Nonstructural Proteins (genetics).
MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.

Abstract

A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.

Affiliations:

Links to Exploration step

Pascal:07-0486627

Le document en format XML

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<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (physiology)</term>
<term>Influenza A virus</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Mechanism of action</term>
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<term>Phenotype</term>
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<term>Strain</term>
<term>Temperature</term>
<term>Viral Nonstructural Proteins (genetics)</term>
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<term>Basse température</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Polymorphisme de conformation simple brin</term>
<term>Protéines virales non structurales (génétique)</term>
<term>Recombinaison génétique</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (physiologie)</term>
<term>Test de complémentation</term>
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<term>Cold Temperature</term>
<term>Genetic Complementation Test</term>
<term>Genotype</term>
<term>Humans</term>
<term>Mutation</term>
<term>Phenotype</term>
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<term>Grippe humaine</term>
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<term>Réversion</term>
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<front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
</front>
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<name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I. I." last="Akopova">I. I. Akopova</name>
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<name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S. G." last="Markushin">S. G. Markushin</name>
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Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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